2014-2017年度科研成果
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科研課題立項 |
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立項名稱 |
主持人 |
項目來源 |
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長鏈非編碼RNA-MALAT1在缺氧肺動脈平滑肌細胞增殖中的作用及分子機制的研究 |
鄭曉東 |
國家自然基金-青年項目 |
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15-HETE/蛋白激酶C-TRPV4信號通路在缺氧性肺動脈高壓發病機制中的作用 |
鄭曉東 |
大慶市科學技術局指導項目 |
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活性氧自由基（ROS）通過調節TRP離子通道參與缺氧肺動脈高壓的機制研究 |
鄭曉東 |
黑龍江省博士后管理辦公室 |
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花生四烯酸介導缺氧活化TRPV4引起肺血管收縮的作用研究 |
鄭曉東 |
哈爾濱醫科大學大慶校區種子基金 |
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胃癌腹腔轉移、小腸Cajal間質細胞凋亡致胃腸動力障礙機制的研究 |
王秀麗 |
哈爾濱醫科大學大慶校區種子基金 |
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結直腸癌中MicroRNA-10b/Beclin 1/Parkin信號通路調控線粒體自噬的機制研究 |
趙濱 |
國家自然科學基金面上項目 |
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自噬蛋白在結直腸癌中的作用機制與臨床應用 |
趙濱 |
黑龍江省自然科學基金面上項目 |
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Kidins220在NGF介導的哮喘小鼠氣道炎癥中的作用 |
倪秀芹 |
省教育廳項目 |
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藍莓花色苷對急性心肌梗死大鼠的保護作用及機制的研究 |
馬萍 |
省教育廳項目 |
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黃芩苷對急性心肌梗死大鼠的保護作用及機制的研究 |
馬萍 |
省中醫藥管理局項目 |
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ATP-P2X4Rs通路在哮喘小鼠氣道炎癥和氣道重塑中的作用 |
倪秀芹 |
省博士后基金 |
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S1PR2/3和ITGB4在HGF介導的血管內皮完整性中的作用 |
倪秀芹 |
中國博士后基金 |
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ATP-P2X4Rs 信號通路在哮喘氣道炎癥和氣道重塑中 的作用 |
倪秀芹 |
國家自然科學基金 |
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P2X4R對卵蛋白致敏小鼠氣道炎癥及Th1/Th2平衡的影響 |
倪秀芹 |
省自然科學基金 |
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P2X7受體在肺動脈高壓肺血管重構中的作用及機制研究 |
倪秀芹 |
省博士后啟動金 |
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P2X4受體拮抗劑通過NF-κB途徑減輕肺動脈高壓發病的機制研究 |
夏青青 |
校內科學研究基金 |
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p2x7在肺動脈高壓血管重構中的作用研究 |
王莉 |
校內科學研究基金 |
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15-HETE調節肺血管外膜纖維化的機制研究 |
張莉 |
教育廳 |
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TRPV3通路在肺動脈高壓中的作用及機制研究 |
曹永剛 |
黑龍江省省自然科學基金 |
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去極化誘導成年小鼠交感神經節細胞內鈣緩慢升高的機制及功能研究 |
孫宏麗 |
國自然 |
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15-LO/15-HETE在缺氧性肺動脈高壓血管外膜重構中的作用及機制研究 |
張莉 |
國自然 |
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15-LO與TGF-β1交互效應在血管外膜重構中的作用機制 |
張莉 |
中國博士后 |
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Galectin-3調節肺血管外膜滋養血管新生的網絡機制 |
張莉 |
省博士后 |
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HSPB1與細胞膜F1F0-ATPase交互效應在肺動脈高壓肺血管滋養血管重構中的作用 |
張莉 |
教育廳 |
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激活AMPK 對缺血后心肌纖維化的保護作用及其機制研究 |
戚漢平 |
省自然 |
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缺氧誘導長鏈非編碼RNA-MEG3引起小鼠肺動脈平滑肌細胞增殖 |
邢妍 |
黑龍江省省自然科學基金 |
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長鏈非編碼RNA-MEG3在缺氧誘導的肺血管重構中的作用 |
邢妍 |
哈爾濱醫科大學創新科學研究基金 |
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長鏈非編碼RNA-MEG3在缺氧小鼠肺血管重構中的作用 |
邢妍 |
大慶市科技局指導項目 |
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5-Fu富集肺癌干細胞群體的表觀遺傳機制 |
石穆穆 |
黑龍江省自然基金 |
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鈣調蛋白在酒精影響大腦皮層神經元中的作用 |
王鵬 |
黑龍江省衛生計生委 |
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鈣敏感受體對孤啡肽調節腦缺血沙鼠認知功能的影響及其機制研究 |
曲麗輝 |
黑龍江省自然科學基金委員會 |
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軟骨寡聚基質蛋白通過BMPs/BMPRII通路介導肺動脈平滑肌細胞表型轉化 |
于航 |
國家自然科學基金-青年基金 |
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鈣調蛋白激酶II在剪應力調節腦血管功能中的作用及機制研究 |
王鵬 |
黑龍江省自然科學基金 |
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COMP 通過BMP2/BMP4 通路介導肺動脈平滑肌表型轉化 |
于航 |
黑龍江省自然科學基金 |
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COMP通過BMP2/BMP4通路介導肺動脈平滑肌表型轉化 |
于航 |
黑龍江省博士后科研啟動金 |
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于維漢院士杰出青年培養基金 |
曲麗輝 |
哈醫大大慶校區 |
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發表科研論文 |
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題目 |
作者 |
期刊 |
級別 |
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Arachidonic Aci - Induced Dilation in Human Coronary Arterioles: Convergence of Signaling Mechanisms on Endothelial TRPV4-Mediated Ca2+ Entry |
Zheng X,ZinkevichNS, Gebremedhin D, Gauthier KM; Nishijima Y, Fang J, Wilcox DA,CampbellWB, Gutterman DD, Zhang DX |
J Am Heart Assoc |
SCI |
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Characterization of blood pressure and endothelial function in TRPV4-deficient mice with L-NAME- and angiotensin II-induced hypertension |
Nishijima Y, Zheng X, Lund H, Suzuki M, Mattson D, Zhang DX |
Physiological Report |
SCI |
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The pattern of Proline, glutamic acid, leucine rich protein 1 expression in Chinese women with primary breast cancer |
Zhang YZ, Wang P, Shi MM, Sasano H, Chan MS, Dai JL, Guo LS, Liu M, Wang XY, Ma Y, Wang L |
Int J Biol Markers |
SCI |
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Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells |
Kai Fan, Xiaolei Li, Yonggang Cao, Hanping Qi, Lei Li,Qianhui Zhang and Hongli Sun |
Anti-Cancer Drugs |
SCI |
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Prognostic significance of proline, glutamic acid, leucine rich protein 1 (PELP1) in triple-negative breast cancer: a retrospective study on 129 cases |
Zhang Y, Dai J, Mcnamara K M, Sasano H, Chan MS, Dai JL, Guo LS, Liu M, Wang XY, Ma Y, Song YL, Wang L |
Bmc Cancer |
SCI |
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Role of endothelial TRPV4 channels in vascular actions of the endocannabinoid, 2-arachidonoylglycerol |
Ho W, Zheng X, Zhang DX |
Br J Pharmacol |
SCI |
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Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function |
Lakshmikanthan S, Zheng X, Nishijima Y, Sobczak M, Szabo A, Vasquez-Vivar J, Zhang D. X, Chrzanowska-Wodnicka M |
EMBO Rep |
SCI |
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MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor beta expression |
Xing Y, Zheng X, Li G, Liao L, Cao W, Xing H, Shen T, Sun L, Yang B, Zhu D |
Int J Biochem Cell Biol |
SCI |
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Autophagy-based survival prognosis in human colorectal carcinoma. |
Yang M, Zhao H, Guo L, Zhang Q, Zhao L, Bai S, Zhang M, Xu S, Wang F, Wang X, Zhao B |
Oncotarget |
SCI |
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CXCR4 over-expression and survival in cancer |
Zhao H, Guo L, Zhao H, Zhao J, Weng H, Zhao B |
Oncotarget |
SCI |
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Pharmacogenomics Discovery and Implementation in GWAS Era |
Xiuqin Ni, Wei Zhang, RS Huang |
Wiley Interdiscip Rev Syst Biol Med |
SCI |
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Expression of neuronal protein Kidins220/ARMS in the spleen and peripheral blood of mice following airway allergen challenge |
Molecular medicine reports |
SCI |
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Matrix metalloproteinase 2 overexpression and prognosis in colorectal cancer : a meta-analysis |
Molecular Biology Reports |
SCI |
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Interaction of Integrin β4 With S1P Receptors in S1P- and HGF-Induced Endothelial Barrier Enhancement |
Ni X, Epshtein Y, Chen W, Zhou T, Xie L, Garcia JG, Jacobson JR. |
Journal of Cellular Biochemistry |
SCI |
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Baicalin alleviates diabetes‑associated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brain‑derived neurotrophic factor and apoptosis |
Ma P, Mao XY, Li XL, Ma Y, Qiao YD, Liu ZQ, Zhou HH, Cao YG. |
MOLECULAR MEDICINE REPORTS |
SCI |
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Effect of P2X4R on airway inflammation and airway remodeling in allergic airway challenge in mice |
Molecular medicine reports |
SCI |
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Crucial role of calcium-sensing receptor activation in cardiac injury of diabetic rats. |
Qi H, Cao Y, Huang W, Liu Y, Wang Y, Li L, Liu L, Ji Z, Sun H. |
PLoS One |
SCI |
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Antiarrhythmic effects and ionic mechanisms of allicin on myocardial injury of diabetic rats induced by streptozotocin |
Huang W1, Wang Y, Cao YG, Qi HP, Li L, Bai B, Liu Y, Sun HL. |
Naunyn-Schmiedeberg’s Arch Pharmacol |
SCI |
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15-LO/15-HETE mediated vascular adventitia fibrosis via p38 MAPK-dependent TGF-β. |
Zhang L, Li Y, Chen M, Su X, Yi D, Lu P, Zhu D. |
J Cell Physiol. |
SCI |
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Tanshinone IIA promotes pulmonary artery smooth muscle cell apoptosis in vitro by inhibiting the JAK2/STAT3 signaling pathway. |
Chen M, Liu Y, Yi D, Wei L, Li Y, Zhang L. |
Cell Physiol Biochem. |
SCI |
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STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration. |
Zhang L, Li Y, Liu Y, Wang X, Chen M, Xing Y, Zhu D. |
J Steroid Biochem Mol Biol. |
SCI |
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Activation of peroxisome proliferator-activated receptor γ (PPARγ) through NF-κB/Brg1 and TGF-β1 pathways attenuates cardiac remodeling in pressure-overloaded rat hearts |
Qi HP1, Wang Y, Zhang QH, Guo J, Li L, Cao YG, Li SZ, Li XL, Shi MM, Xu W, Li BY, Sun HL. |
Cellular Physiology and Biochemistry |
SCI |
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MicroRNA-30c contributes to the development of hypoxia pulmonary hypertension by inhibiting platelet-derived growth factor receptor β expression. |
Xing Y, Zheng X, Li G, Liao L, Cao W Xing H, Shen T, Sun L, Yang B, Zhu D. |
Int J Biochem Cell Biol. |
SCI |
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Elk-1-mediated 15-Lipoxygenase Expression is Required for Hypoxia-induced Pulmonary Vascular Adventitial Fibroblast Dynamics. |
Li Y, Zhang L, Wang X, Chen M, Liu Y, Xing Y, Wang X, Gao S, Zhu D. |
Acta Physiol |
SCI |
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TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts |
Zhang L, Chen Y, Li G, Chen M, Huang W, Liu Y, Li Y. |
Lipids Health Dis. |
SCI |
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Combination of microRNA-21 and microRNA-146a attenuates cardiac dysfunction and apoptosis during acute myocardial infarction in mice. |
Wei Huang, Shanshan Tian, Pengzhou Hang, Chuan Sun, Jing Guo, Zhimin Du. |
Molecular Therapy-Nucleic Acids. |
SCI |
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Fluorouracil selctively enriches stem-like cells in the lung adenocarcinoma cell line SPC |
石穆穆 |
Tumor Biol |
SCI |
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Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II |
Wang, Yanli; Yue, Weidong; Wang, Wei; Yu, Juan; Liu, Ruxia; Wang, Peng; Cao, Yonggang; Zhang, Qianlong; Wang, Xiaoyan; Qu, Lihui |
NeuroReport |
SCI |
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Inward rectifier K+ currents are regulated by CaMKII in endothelial cells of primarily cultured bovine pulmonary arteries |
Lihui Qu, Lei Yu, Yanli Wang, Xin Jin, Qianlong Zhang, Ping Lu, Xiufeng Yu, Weiwei Zhong, Xiaodong Zheng, Ningren Cui, Chun Jiang, and Daling Zhu |
PLoS One |
SCI |
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Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus |
Peng Wang, Yonggang Cao, Juan Yu, Ruxia Liu, Bing Bai, Hanping Qi, Qianlong Zhang, Wenguang Guo, Hui Zhu, Lihui Qu |
Brain Research |
SCI |
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Allicin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathway |
Juan Yu, Ru-Xia Liu, Peng Wang, Yong-Gang Cao, Qian-Long Zhang, Hui Qiao, Qian Luo, Shu-Zhi Li, Chang-Lin Jiang, Li-Hui Qu |
Int J Clin Exp Med |
SCI |
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Carvacrol induces the apoptosis of pulmonary artery smooth muscle cells under hypoxia |
張倩龍 |
European Journal of Pharmacology |
SCI |
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科研成果獎 |
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成果名稱 |
完成人 |
獎勵名稱 |
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《M3受體—心肌保護的新靶點》 |
孫宏麗 |
教育部高等學校自然科學一等獎 |
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《三氧化二砷持續緩慢靜脈輸注法對白血病和實體癌的治療研究》 |
孫宏麗 |
教育部提名國家科技進步一等獎 |
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《三氧化二砷毒性反應發生機制及防治策略》 |
孫宏麗 |
中華醫學科技一等獎 |
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《心源性猝死發生及藥物干預新調控點研究》 |
孫宏麗 |
黑龍江省政府科學技術進步一等獎 |
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《氧化苦參堿心肌保護作用靶點的研究》 |
孫宏麗 |
黑龍江省政府科學技術自然科學二等獎 |
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《Choline-modulated arsenic trioxide-induced prolongation of cardiac repolarization in guinea pig》 |
孫宏麗 |
黑龍江省自然科學技術學術成果一等獎 |
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《Cardioprotective effects and underlying mechanisms of oxymatrine against ischemic myocardial injuries of rats》 |
孫宏麗 |
黑龍江省自然科學技術學術成果二等獎 |
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孤啡肽對大鼠頂葉皮層神經元鉀離子通道調節作用機制的研究 |
曲麗輝 |
黑龍江省政府科學技術進步二等獎 |
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孤啡肽對大鼠頂葉皮層神經元鉀離子通道調節作用機制的研究 |
曲麗輝 |
黑龍江省衛生計生委科技成果一等獎 |
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Kidins220/ARMS在卵蛋白致敏小鼠氣道炎癥和氣道高反應性中的作用 |
倪秀芹 |
黑龍江省衛生計生委科技成果一等獎 |
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15-lipoxygenase/15-hydroxyeicosatetraenoic acid mediates rat vascular adventitia fibrosis via p38 MAPK-dependent transforming growth factor-β1/Smad pathways. 15LO/15HETE通過依賴轉化生長因子的P38MAPK信號通路調節動脈血管外膜纖維化研究 |
張莉 |
大慶市第二十五屆自然科學技術學術成果一等獎 |
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Interaction of Integrin β4 With S1P Receptors in S1P- and HGF-Induced Endothelial Barrier Enhancement （整合素β4和S1P受體相互作用在S1P和HGF誘導的內皮屏障增強中的作用） |
倪秀芹 |
大慶市第二十五屆自然科學技術學術成果一等獎 |
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Antioxidant Mechanism of Rutin on Hypoxia-induced Pulmonary Arterial Cell Proliferation (蘆丁的抗氧化機制在缺氧誘導肺動脈細胞增殖中的作用) |
鄭曉東 |
大慶市第二十五屆自然科學技術學術成果三等獎 |
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Nociceptin/orphanin FQ-induced inhibition of delayed rectifier potassium currents by calcium/calmodulin-dependent protein kinase type II （Ca2+-CaM-CaMKII在孤啡肽抑制延遲整流鉀離子電流中的作用研究） |
曲麗輝 |
大慶市第二十五屆自然科學技術學術成果三等獎 |
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The pattern of proline, glutamic acid, and leucine-rich protein 1 expression in Chinese women with primary breast cancer（脯氨酸-谷氨酸-亮氨酸富集蛋白-1在中國女性原發性乳腺癌中表達模式的研究） |
王麟 |
大慶市第二十五屆自然科學技術學術成果三等獎 |
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藍莓花色苷預處理對大鼠心肌梗死的保護作用 |
馬萍 |
大慶市第二十五屆自然科學技術學術成果三等獎 |
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